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Glutamine: A Review of Its Role, Benefits, and Limitations

Last Updated: September 19, 2025

Abstract Glutamine is the most abundant free amino acid in human plasma and skeletal muscle. Although it is classified as a non-essential amino acid, it becomes “conditionally essential” during times of stress, illness, or intense physical exertion. This paper reviews its biochemical roles, potential clinical and athletic applications, supplementation protocols, and current limitations in research....